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About This Item
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
99% (NMR)
form
powder
packaging
pkg of 1 × 100 mg (880134P-100mg)
pkg of 1 × 500 mg (880134P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[N+](C)(C)CCOC(C(C)(CC(C)([H])C(OCCCC)=O)CSCCC(OC)=O)=O.[Cl-]
InChI
1S/C21H40NO6S.ClH/c1-8-9-12-27-19(24)17(2)15-21(3,16-29-14-10-18(23)26-7)20(25)28-13-11-22(4,5)6;/h17H,8-16H2,1-7H3;1H/q+1;/p-1
InChI key
OEHGLUZNEWMIMQ-UHFFFAOYSA-M
Related Categories
General description
PMA (polymethacrylate) random copolymer is amphiphilic and consists of hydrophobic and hydrophilic sidechains.
Biochem/physiol Actions
PMA (polymethacrylate) forms nanodiscs spontaneously by fragmentation or solubilization of the lipid bilayers. It is used in designing of nanodisc-forming polymer to mimic the amphiphilic nature of proteins and peptides. PMA N−C4−60−4.7 efficiently solubilised the lipid membrane and forms lipid nanodiscs with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The addition of PMA N−C4−60−4.7 lowered the light scattering intensity of Escherichia coli suspension.
Packaging
20mL clear glass screw cap vial (880134P-500mg)
5mL glass amber screw cap vial (880134P-100mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers
Yasuhara K, et al.
Journal of the American Chemical Society, 139(51), 18657-18663 (2017)
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8
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