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Merck
CN

890870C

Avanti

16:0 TAP

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dipalmitoyl-3-trimethylammonium-propane (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C38H76NO4Cl
CAS Number:
139984-36-4
Molecular Weight:
646.47
MDL number:
MFCD22495361
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

16:0 TAP, Avanti Research™ - A Croda Brand 890870C

InChI

1S/C38H76NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-37(40)42-35-36(34-39(3,4)5)43-38(41)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h36H,6-35H2,1-5H3;1H/q+1;/p-1

InChI key

KYARZEFZZOGPGS-UHFFFAOYSA-M

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Cl-]

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (890870C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890870C

concentration

10 mg/mL (890870C-25mg)

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

Application

1,2-dipalmitoyl-3-trimethylammonium-propane (16:0 TAP) is suitable to prepare lipid monolayer/liposome:
  • to mimic the presence of the cationic charge localized in the membrane for understanding the electrostatic effects in the biological membranes and to study its interaction with zearalenone and selenate ions
  • to study its effect on the L-pro catalyzed reaction
  • to serve as a positive control, to determine the effectiveness of anionic phospholipids for pro-inflammatory responses

Biochem/physiol Actions

1,2-dipalmitoyl-3-trimethylammonium-propane (16:0 TAP) liposomes are known to promote elevated pro-inflammatory responses.

General description

1,2-dipalmitoyl-3-trimethylammonium-propane (16:0 TAP) is a cationic lipid and a diol based transfection reagent.

Packaging

5 mL Clear Glass Sealed Ampule (890870C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Regulatory Information

危险化学品
易制毒化学品（2类）
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Detection of L-Proline-Catalyzed Michael Addition Reaction in Model Biomembrane
Hirose M, et al.
Journal of Chemistry, 2019 (2019)
Barbara Gzyl-Malcher et al.
The Journal of membrane biology, 250(3), 273-284 (2017-04-30)
The impact of zearalenone and selenate ions on the monolayers of 1,2-dipalmitoyl-phosphatidylcholine (DPPC), 1,2-dipalmitoyl-3-trimethylammonium-propane (DPTAP), and the lipid mixtures (phospholipids and galactolipids) extracted from wheat plasmalemma has been studied using Langmuir trough technique and Brewster angle microscopy (BAM). The zearalenone
Naomi Benne et al.
Journal of controlled release : official journal of the Controlled Release Society, 291, 135-146 (2018-10-27)
Atherosclerosis is the predominant underlying pathology of many types of cardiovascular disease and is one of the leading causes of death worldwide. It is characterized by the retention of oxidized low-density lipoprotein (ox-LDL) in lipid-rich macrophages (foam cells) in the
Chun Liufu et al.
International journal of nanomedicine, 14, 8923-8941 (2019-12-10)
Cancer stem cells (CSCs) are responsible for cancer therapeutic resistance and metastasis. To date, in addition to surgery, chemotherapy, and radiotherapy, gene delivery has emerged as a potential therapeutic modality for ovarian cancer. Efficient and safe targeted gene delivery is
Bao Zhu et al.
Chemosphere, 247, 125876-125876 (2020-01-25)
Aluminium oxide nanoparticles (Al2O3 NPs) potentially cause health hazards after their release into the environment. The crystalline phase of Al2O3 NPs determines their surface structure and the number of functional groups. The adsorption of natural organic matter (NOM) or biomolecules
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