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890895P

Avanti

18:1 TAP (DOTAP, MS Salt)

Name: 18:1 TAP (DOTAP, MS Salt)
Brand: AVANTI

Avanti Polar Lipids 890895P, powder

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Synonym(s):

1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt)

Empirical Formula (Hill Notation):

C₄₃H₈₃NO₈S

CAS Number:

144189-73-1

Molecular Weight:

774.19

NACRES:

NA.25

form

powder

packaging

pkg of 2 × 100 mg (890895P-200mg)
pkg of 1 × 25 mg (890895P-25mg)

manufacturer/tradename

Avanti Polar Lipids 890895P

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.O=S([O-])(OC)=O

InChI

1S/C42H80NO4.CH4O4S/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;1-5-6(2,3)4/h20-23,40H,6-19,24-39H2,1-5H3;1H3,(H,2,3,4)/q+1;/p-1/b22-20-,23-21-;

InChI key

RSMRWWHFJMENJH-LQDDAWAPSA-M

Biochem/physiol Actions

1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) is a cationic lipid, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890895P-200mg)

5 mL Clear Glass Sealed Ampule (890895P-25mg)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells.

Sabata Martino et al.

Journal of biomedicine & biotechnology, 2009, 410260-410260 (2009-06-09)

RNA interference technology is an ideal strategy to elucidate the mechanisms associated with human CD34(+) hematopoietic stem cell differentiation into dendritic cells. Simple manipulations in vitro can unequivocally yield alloreactive or tolerogenic populations, suggesting key implications of biochemical players that

DOTAP (and other cationic lipids): chemistry, biophysics, and transfection.

Dmitri Simberg et al.

Critical reviews in therapeutic drug carrier systems, 21(4), 257-317 (2005-01-11)

Cationic lipid-mediated nucleic acid and protein delivery is becoming increasingly popular for in vitro and in vivo applications. While the chemistry of cationic lipid carriers is moving very rapidly, and more and more sophisticated molecules are being developed, it is

DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.

Bieong-Kil Kim et al.

Biochimica et biophysica acta, 1848(10 Pt A), 1996-2001 (2015-06-27)

The effects of lipid compositions on their physicochemical properties and transfection efficiencies were investigated. Four liposome formulations with different 1,2-dioleoyl-3-trimethylammoniumpropane (DOTAP) to dioleoylphosphatidylethanolamine (DOPE) weight ratios were investigated, that is, weight ratios 1:0 (T1P0), 3:1 (T3P1), 1:1 (T1P1), and 1:3

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