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Merck
CN

900125E

Avanti

17(S)-HDHA

Avanti Research™ - A Croda Brand

Synonym(s):

17(S)-hydroxy Docosahexaenoic acid

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About This Item

Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
92693-03-3
Molecular Weight:
344.49
MDL number:
MFCD18427951
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

17(S)-HDHA, Avanti Research™ - A Croda Brand 900125E, ethanol solution

InChI

1S/C22H32O3/c1-2-3-15-18-21(23)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-22(24)25/h3,5-8,11-16,19,21,23H,2,4,9-10,17-18,20H2,1H3,(H,24,25)/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+/t21-/m0/s1

InChI key

SWTYBBUBEPPYCX-YTQNUIGOSA-N

SMILES string

CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O

assay

>99% (TLC)

form

ethanol solution

packaging

pkg of 1 × 1 mL (900125E-100ug)
pkg of 1 × 1 mL (900125E-500ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 900125E

concentration

0.1 mg/mL (900125E-100ug)
0.5 mg/mL (900125E-500ug)

lipid type

neutral lipids
neutral glycerides

shipped in

dry ice

storage temp.

−70°C

Biochem/physiol Actions

Docosahexaenoic acid (DHA) exhibits various physiological processes such as regulating signal transduction pathways, neurotransmission, production of neurons and formation of myelin sheath around the axon. It is also associated with the membrane receptor function and synaptic plasticity. DHA supports membrane integrity, fluidity and organization. It is also found to be involved in neuroinflammation. DHA plays a vital role in the development and maturation of the brain. 17(S)-HDHA (hydroxy docosahexaenoic acid) can serve as a precursor for specialized pro-resolving mediators (D-series).

General description

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (PUFA) with 22 carbons and six double bonds. The first double bond occurring at position three from the methyl terminus (22:6 n-3). DHA is a component of phospholipid membranes and the myelin sheath. It is the most abundant PUFA found in the brain and localized predominantly to the gray matter.

Packaging

2 mL Amber Glass Sealed Ampule (900125E-100ug)
2 mL Amber Glass Sealed Ampule (900125E-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

55.4 °F - closed cup

flash_point_c

13.0 °C - closed cup

Regulatory Information

危险化学品
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Michael J Weiser et al.
Nutrients, 8(2), 99-99 (2016-02-24)
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid (PUFA) found in the brain and can affect neurological function by modulating signal transduction pathways, neurotransmission, neurogenesis, myelination, membrane receptor function, synaptic plasticity, neuroinflammation, membrane integrity and membrane organization.
Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition, 460-460 (2019)
Miaomiao Ruan et al.
Journal of the neurological sciences, 396, 247-253 (2018-12-12)
Glioblastoma (GBM) is a typical malignant tumor, and there are no effective drugs capable of improving patient survival. Docosahexaenoic acid (DHA), a nutrient essential to animal health and neurodevelopment, exerts an anticancer effect in several types of cancer. However, the

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