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Merck
CN

900128E

Avanti

15(S)-HETE

Avanti Research™ - A Croda Brand

Synonym(s):

15S-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid

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About This Item

Empirical Formula (Hill Notation):
C20H32O3
CAS Number:
54845-95-3
Molecular Weight:
320.47
MDL number:
MFCD00063590
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

15(S)-HETE, Avanti Research™ - A Croda Brand, ethanol solution

assay

>99% (TLC)

InChI key

JSFATNQSLKRBCI-VAEKSGALSA-N

SMILES string

O[C@@H](CCCCC)\C=C\C=C/C\C=C/C\C=C/CCCC(=O)O

InChI

1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1

form

ethanol solution

packaging

pkg of 1 × 1 mL (900128E-100UG)
pkg of 1 × 1 mL (900128E-500UG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

100 μg/mL in ethanol (900128E-100UG)
500 μg/mL in ethanol (900128E-500UG)

shipped in

dry ice

storage temp.

−70°C

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Biochem/physiol Actions

15(S)-HETE plays a role in various biological actions. It may play a role in pathogenesis and prevention of airway inflammatory disorders. 15(S)-HETE is involved in inhibiting cell proliferation and induces apoptosis in various human cancers.

General description

15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).

Packaging

2 mL Amber Glass Sealed Ampule (900128E-100UG and 900128E-500UG)

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

55.4 °F

flash_point_c

13 °C

Regulatory Information

危险化学品
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15 (S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis
Profita M, et al.
American Journal of Physiology. Cell Physiology, 279(4), C1249-C1258 (2000)
Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of

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