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A-155

Acetylsalicylic Anhydride (Aspirin Impurity F) solution

100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H14O7
CAS Number:
1466-82-6
Molecular Weight:
342.30
NACRES:
NA.24
UNSPSC Code:
12352200
MDL number:
MFCD00013236
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grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

InChI

1S/C18H14O7/c1-11(19)23-15-9-5-3-7-13(15)17(21)25-18(22)14-8-4-6-10-16(14)24-12(2)20/h3-10H,1-2H3

InChI key

OAWXYINGQXLWOE-UHFFFAOYSA-N

General description

Acetylsalicylic Anhydride (ASN) is considered to be an immunogenic impurity of aspirin and the allergic reactions to the drug are attributed to the presence of this impurity.

Application

Acetylsalicylic Anhydride (ASN) may be used as a pharmaceutical reference standard for the determination of trace amounts of analyte in aspirin samples and aspirin formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Regulatory Information

新产品

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Certificates of Analysis (COA)

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Application of gas-liquid chromatography and high-performance liquid chromatography to the analysis of trace amounts of salicylic acid, acetylsalicylic anhydride and acetylsalicylsalicylic acid in aspirin samples and aspirin formulations
Ali Syed Laik
Journal of Chromatography A, 126, 651-663 (1976)
Isolation of salicylsalicylic acid, acetylsalicylsalicylic acid, and acetylsalicylic anhydride from aspirin tablets by extraction and high-pressure liquid chromatography
Reepmeyer JC and Kirchhoefer RD
Journal of Pharmaceutical Sciences, 68(9), 1167-1169 (1979)
Quantitative determination by high-performance liquid chromatography of acetylsalicylic acid and related substances in tablets
Verstraeten A, et al.
Journal of Chromatography A, 388(9), 201-216 (1987)

Global Trade Item Number

SKUGTIN
SML1217-5MG04061832786858
SML1217-25MG04061832786841
ABE131204055977113600
SAB1105838-200UL04061835640652
SAB1100531-200UL04061837157431
SAB6012270-100UL04065273194388
SAB4504755-100UG04061832527857
SAB4301380-100UL04061837438387
SAB4504718-100UG04061832527666
HMI0255-5NMOL04061828852956
HMI0254-5NMOL04061831381580
MLTUD008004061836087241
HLMIR025504061836734848
HLTUD025404061836753641
HLMIR025404061836734831
HLTUD025504061836088385
MLMIR007904061836707088
MLMIR008004061836707095
MLTUD007904061836087234
GF66544634-2EA04061825060262
GF66544634-5EA04061825060279
GF66544634-1EA04061825060255
GF59351317-1EA04061825477527
648462-1KG07790788052102
648462-3KG04055977262391