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Merck
CN

A-913

7-Aminonitrazepam solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O
CAS Number:
4928-02-3
Molecular Weight:
251.28
NACRES:
NA.24
PubChem Substance ID:
329771036
UNSPSC Code:
41116107
EC Number:
200-835-2
MDL number:
MFCD00800998

Key Documents

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Product Name

7-Aminonitrazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

InChI key

OYOUQHVDCKOOAL-UHFFFAOYSA-N

InChI

1S/C15H13N3O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9,16H2,(H,18,19)

SMILES string

O=C1NC2=CC=C(N)C=C2C(C3=CC=CC=C3)=NC1

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

Quality Level

300

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General description

7-Aminonitrazepam is a major urinary metabolite of nitrazepam, a benzodiazepine used to treat insomnia and sold under the trade names Mogadon and Alodorm. This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, or urine drug monitoring of nitrazepam use.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Takeno et al.
Toxicology and applied pharmacology, 121(2), 233-238 (1993-08-01)
This study was designed to evaluate the developmental toxicity of nitrazepam (NZ) in Sprague-Dawley rats and ICR mice and to determine the metabolic factors which modulate susceptibility to the developmental effects of NZ. Rats were treated orally with a single
Yu Zhu et al.
Se pu = Chinese journal of chromatography, 20(5), 394-397 (2005-12-20)
A highly sensitive method has been developed for the analysis of 7-aminonitrazepam (7-ANIZ), the major metabolite of nitrazepam, in urine by trimethylsilyl derivatization-gas chromatography/mass spectrometry. Urine samples were extracted with ethyl ether-ethyl acetate (99:1, volume ratio). The extracts were derivatized
B J Hart et al.
Methods and findings in experimental and clinical pharmacology, 10(1), 21-26 (1988-01-01)
The stability of some selected benzodiazepines in saliva has been studied. The benzodiazepines nitrazepam and clonazepam were found to be unstable in saliva at room temperature and nitrazepam was converted into 7-aminonitrazepam. The conversion rate of nitrazepam was strongly dependent
M Tomita et al.
Journal of chromatography, 621(2), 249-255 (1993-11-24)
We applied micellar electrokinetic capillary chromatography to simultaneous separation and determination of nitrazepam and its major metabolites, 7-aminonitrazepam and 7-acetamidonitrazepam, in spiked urine. Prior to electrophoresis, the three compounds were successfully extracted from the spiked urine with commercial disposable solid-phase
High-performance liquid chromatographic determination of nitrazepam and its metabolites in human urine.
T Kozu
Journal of chromatography, 310(1), 213-218 (1984-09-14)
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