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Merck
CN

N-057

Supelco

Noratropine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Noratropine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H21NO3·HCl
CAS Number:
537-29-1
Molecular Weight:
311.80
EC Number:
200-659-6
UNSPSC Code:
41116107

Key Documents

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grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

InChI

1S/C16H21NO3.ClH/c18-10-15(11-4-2-1-3-5-11)16(19)20-14-8-12-6-7-13(9-14)17-12;/h1-5,12-15,17-18H,6-10H2;1H/t12-,13-,15?;/m1./s1

InChI key

JBSGQNAULGFCJE-JAWPBFRBSA-N

General description

The primary metabolite of atropine, an anticholinergic drug used in opthalmology, resuscitation from cardiac arrest, and treatment for organophosphate poisoning. A Certified Solution Standard for use in LC or GC applications.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preparation of noratropine by oxidative n-demethylation of atropine.
M J Van der Meer et al.
The Journal of pharmacy and pharmacology, 35(6), 408-408 (1983-06-01)
Mohamad Houssam Al Balkhi et al.
Phytochemistry, 74, 105-114 (2011-11-16)
The presence of two compounds, norlittorine and norhyoscyamine, has been reported in leaves and roots of Datura innoxia; however their metabolic origin in the tropane alkaloid pathway has remained unknown. Precise knowledge of this pathway is a necessary pre-requisite to
M J Van der Meer et al.
The Journal of pharmacy and pharmacology, 38(10), 781-784 (1986-10-01)
A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal volunteer is proposed. Noratropine (24%), atropine-N-oxide (equatorial isomer) (15%), tropine (2%)

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