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About This Item
UNSPSC Code:
12161503
NACRES:
NA.46
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Compatibility:
for use with FemtoQuest™ instrument
General description
Tumor Necrosis Factor alpha (TNFα) and Interleukin-6 (IL-6) are two important cytokines with diverse functions in the immune system. TNFα induces inflammatory signaling pathways and IL-6 regulates the balance between pro-inflammatory and anti-inflammatory processes. Both TNFα and IL-6 are targets for therapeutic intervention in various inflammatory and autoimmune diseases, making them important molecules for drug development and treatment strategies.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
- Multiplexed Analysis: Detect two distinct analytes from a single sample, doubling your analytical output while preserving valuable sample volume for additional testing needs.
- Exceptional Detection Limits: Achieve femtogram/mL sensitivity levels, unlocking the ability to quantify trace biomarkers that conventional assays cannot reliability measure.
- Batch-to-Batch Consistency: Lot matched reagent components eliminate variability between kit lots, ensuring reproducibile performance across your entire study.
- Integreated QC Solution: QC materials with step-by-step preparation protocols for 2-3 control levels ensure robust assay performance monitoring.
- Cost-Effective Solution: Reduce per-sample costs through multiplexed analysis while maintaining premium performance standards.
- Enhanced Understanding of Inflammation: Measuring both TNFα and IL-6 together provides a more comprehensive view of the inflammatory response, as these cytokines often interact in the pathogenesis of autoimmune diseases.
Packaging
96 well assay
Analysis Note
TNFα:
- Sensitivity: LLOQ 20 fg/mL *(FemtoQuest™ Instrument)
- Standard Curve Range: 10-50,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Parallelism: Plasma 103%, Serum 103%
- Recovery: Plasma 91%, Serum 82%
- Sensitivity: LLOQ 60 fg/mL *(FemtoQuest™ Instrument)
- Standard Range: 30-150,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Parallelism: Plasma 104%, Serum 93%
- Recovery: Plasma 101%, Serum 97%
Other Notes
Although IL-6 was detectable in non-human primate, mouse, rat, and canine samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Regulatory Information
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Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 03-0216-2P | 04065272037853 |