04-1518
Anti-PD-1 Antibody, clone RMP1-14
clone RMP1-14, from rat
Synonym(s):
Programmed cell death protein 1, Protein PD-1, mPD-1, CD279
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
General description
32 kDa calculated
PD-1 (Programmed cell death protein 1, CD279) is a single-pass type 1 transmembrane protein that contains an Ig-like V-type domain on the extracellular region and a tyrosine-based motif on the intracellular region. PD-1 functions as an immunoreceptor that is activated by the PD-L1 ligand. PD-1 is expressed on the surface of activated T- and B-cells. It plays an inhibitory role on T-cell function, and may block T-cell—mediated events such as the proliferation of lymphocytes and the secretion of cytokines. PD-1 may therefore negatively regulate immune responses, and disruption of PD-1 function may affect tolerance.
Immunogen
Epitope: Extracellular Domain
Recombinant protein corresponding to mouse PD-1.
Application
Detect PD-1 using this Anti-PD-1 Antibody, clone RMP1-14 validated for use in Flow Cytometry.
Research Category
Signaling
Signaling
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Physical form
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
BHK cells
BHK cells
Evaluated by Flow Cytometry in BHK cells.
Flow Cytometry Analysis: 0.5 µg of this antibody detected PD-1 in BHK cells.
Flow Cytometry Analysis: 0.5 µg of this antibody detected PD-1 in BHK cells.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ryoichi Saito et al.
Cancer research, 78(14), 3954-3968 (2018-05-23)
High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-CreERT2; Trp53L/L; PtenL/L;