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Merck
CN

04-638

Anti-TRF1 Antibody, clone BED5 57-6

clone BED5 57-6, Upstate®, from mouse

Synonym(s):

TERF1, telomeric repeat binding factor (NIMA-interacting) 1, FLJ41416, PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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Product Name

Anti-TRF1 Antibody, clone BED5 57-6, clone BED5 57-6, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

BED5 57-6, monoclonal

species reactivity

mouse, rat, hamster, monkey, human

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

immunofluorescence: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

ambient

target post-translational modification

unmodified

Quality Level

Gene Information

human ... TERF1(7013)

Physical form

Format: Purified
Affinity purified immunoglobulin in PBS with 0.05% NaN3

Biochem/physiol Actions

Detects TRF1

General description

~60 kDa

Immunogen

Human TRF1 protein

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Analysis Note

Routinely evaluated by Western Blot on HeLa cell lysate.

Application

This Anti-TRF1 Antibody, clone BED5 57-6 is validated for use in WB, IF for the detection of TRF1.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PTOP and TRF1 help enhance the radio resistance in breast cancer cell.
Li, Z; Yang, X; Xia, N; Yang, L; Yu, H; Zhou, F; X, C; Zhou, Y
Cancer Cell International null
Emily Mason-Osann et al.
EMBO reports, 21(6), e49495-e49495 (2020-04-28)
Cancer cells can activate the alternative lengthening of telomeres (ALT) pathway to promote replicative immortality. The ALT pathway promotes telomere elongation through a homologous recombination pathway known as break-induced replication (BIR), which is often engaged to repair single-ended double-stranded breaks

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"Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. These changes can be cell- or tissue-specific, and can be passed on to multiple generations. Epigenetic regulation enriches DNAbased information, allowing a cell to vary its response across diverse biological and environmental contexts. Although epigenetic mechanisms are primarily centered in the nucleus, these mechanisms can be induced by environmental signals such as hormones, nutrients, stress, and cellular damage, pointing to the involvement of cytoplasmic and extracellular factors in epigenetic regulation."

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