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05-1109

Sigma-Aldrich

Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01

clone C-PEP-01, from mouse

Synonym(s):

CD220 antigen, insulin receptor

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1 MG
CN¥4,906.99

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

CN¥4,906.99

Estimated to ship onOctober 27, 2025Details

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C-PEP-01, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)

isotype

IgG1

UniProt accession no.

P01308

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Anti-Phospho-INSR-pY1185 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB1300729

Anti-Phospho-INSR-pY1185 antibody produced in rabbit

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

affinity isolated antibody

species reactivity

human

species reactivity

mouse, human, rat

species reactivity

mouse, rat (demonstrated by independent lab), human

species reactivity

human

biological source

mouse

biological source

rabbit

biological source

mouse

biological source

rabbit

clone

C-PEP-01, monoclonal

clone

polyclonal

clone

CT-3, monoclonal

clone

polyclonal

technique(s)

immunohistochemistry: suitable (paraffin)

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

dot blot: suitable, indirect ELISA: 1:1000

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

General description

Approx. 12 kDa
Pro-Insulin consists of the three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the Insulin molecule). From every molecule of Pro-Insulin, one molecule of Insulin plus one molecule of C-peptide are produced. C-peptide is released into the blood stream in equal amounts to Insulin.

Immunogen

Synthetic C-peptide of human pro-insulin conjugated to bovine serum albumin.

Application

Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling
This Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 is validated for use in IH(P) for the detection of Pro-Insulin C-Peptide.

Biochem/physiol Actions

No cross-reactivity with Insulin or other peptide hormones or proteins was observed.
The antibody C-PEP-01 reacts specifically with C-peptide, a part of the Pro-insulin molecule.

Physical form

Format: Purified
Mouse monoclonal IgG1 in phosphate buffered saline, pH7.4, and 15 mM sodium azide.
Sequential precipitation with caprylic acid and ammonium sulfate.

Preparation Note

Store at 2-8°C and use within 1 year from date of receipt.

Analysis Note

Control
Human normal pancreas tissue
Evaluated by Immunohistochemistry in normal human pancreas.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: CBL94

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

    • Certificates of Analysis (COA)

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    Mohammad Massumi et al.
    PloS one, 11(10), e0164457-e0164457 (2016-10-19)
    The ability to yield glucose-responsive pancreatic beta-cells from human pluripotent stem cells in vitro will facilitate the development of the cell replacement therapies for the treatment of Type 1 Diabetes. Here, through the sequential in vitro targeting of selected signaling
    Mahmoud M Gabr et al.
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    Sapna Puri et al.
    Nature communications, 9(1), 485-485 (2018-02-06)
    Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In contrast, proliferation is robust in neonatal β cells that are functionally
    Sunghee Chai et al.
    Human gene therapy, 33(15-16), 789-800 (2022-03-18)
    Diabetes mellitus, caused by loss or dysfunction of the insulin-producing beta cells of the pancreas, is a promising target for recombinant adeno-associated virus (rAAV)-mediated gene therapy. To target potential therapeutic payloads specifically to beta cells, a cell type-specific expression control
    Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.
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