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Merck
CN

05-185

Sigma-Aldrich

Anti-avian Src Antibody, clone EC10

clone EC10, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

EC10, monoclonal

species reactivity

avian

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_005417.3
NM_198291.1

UniProt accession no.

P12931

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SRC(6714)

General description

60 kDa

Immunogen

Recombinant chicken pp60src

Application

Anti-avian Src Antibody, clone EC10 detects level of avian Src & has been published & validated for use in IP, WB & IC.

Biochem/physiol Actions

specific only for avian Src; this antibody is excellent for distinguishing pp60src in cells transfected with v-src or c-src expression vectors.

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, with 0.05% sodium azide
Format: Purified

Analysis Note

routinely evaluated in (60kDa) on a RIPA lysate of chicken embryo fibroblasts (CEF)

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity.
David B Alexander, Hitoshi Ichikawa, John F Bechberger, Virginijus Valiunas, Misao Ohki et al.
Cancer Research null
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.
Reynolds, A B, et al.
Molecular and cellular biology, 9, 629-638 (1989)
Wanping Xu et al.
Molecular cell, 47(3), 434-443 (2012-06-26)
Many critical protein kinases rely on the Hsp90 chaperone machinery for stability and function. After initially forming a ternary complex with kinase client and the cochaperone p50(Cdc37), Hsp90 proceeds through a cycle of conformational changes facilitated by ATP binding and
Tulsiram Prathapam et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(8), 2695-2700 (2006-02-16)
The transcription factor Myc plays a central role in the control of cellular proliferation. Myc expression is induced by growth factors in a pathway mediated by cellular Src (c-Src), but it is not clear whether Myc induction or activity is
Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays.
Toyli, M; Rosberg-Kulha, L; Capra, J; Vuoristo, J; Eskelinen, S
Laboratory Investigation; a Journal of Technical Methods and Pathology null
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