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Merck
CN

05-1938

Anti-G3BP1 Antibody, clone 14E5-G9

clone 14E5-G9, from mouse

Synonym(s):

ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, GAP binding protein, GTPase activating protein (SH3 domain) binding protein 1, Ras-GTPase-activating protein SH3-domain-binding protein, RasGAP-associated endoribonuclease G3BP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody product type

primary antibodies

clone

14E5-G9, monoclonal

species reactivity

human

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_005745.1

UniProt accession no.

Q13283

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... G3BP1(10146)

General description

G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.
52 kDa

Immunogen

GST-tagged recombinant protein corresponding to human G3BP1.

Application

Anti-G3BP1 Antibody, clone 14E5-G9 is an antibody against G3BP1 for use in WB & IC.
Research Sub Category
RNA Metabolism & Binding Proteins

G-proteins

Biochem/physiol Actions

This antibody recognizes G3BP1.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected G3BP1 on K562 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

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Yu Sun et al.
Nature communications, 11(1), 3354-3354 (2020-07-06)
Expansion of an intronic (GGGGCC)n repeat region within the C9orf72 gene is a main cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). A hallmark of c9ALS/FTD is the accumulation of misprocessed RNAs, which are often targets of cellular

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