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About This Item
Empirical Formula (Hill Notation):
C31H41N6O7 · Na
Molecular Weight:
632.68
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A highly potent and selective ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus 2.5 µM for ETB).
A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).
Biochem/physiol Actions
Cell permeable: no
Primary Target
ETA (endothelin) receptor antagonist
ETA (endothelin) receptor antagonist
Product does not compete with ATP.
Reversible: no
Target Ki: 40 nM for ETA versus 2.5 µM for ETB
Packaging
Yes
Physical form
Supplied as a sodium salt. Sold on the basis of peptide content.
Other Notes
Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp, Na)
Nambi, P., et al. 1996. J. Pharmacol. Exp. Ther.277, 1567.
Bax, W.A., and Saxena, P.R. 1994. Trends Pharmacol. Sci. 15, 379.
Ihara, M., et al. 1991. Biochem. Biophys. Res. Commun. 178, 132.
Bax, W.A., and Saxena, P.R. 1994. Trends Pharmacol. Sci. 15, 379.
Ihara, M., et al. 1991. Biochem. Biophys. Res. Commun. 178, 132.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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