06-203
Anti-SHC Antibody
Upstate®, from rabbit
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
species reactivity
pig, rat, human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Quality Level
Gene Information
human ... SHC1(6464)
General description
46, 52, 66 kDa
Immunogen
Recombinant GST fusion protein corresponding to amino acids 366-473 of human SHC-SH2
Application
Anti-SHC Antibody is an antibody against SHC for use in IH, IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Biochem/physiol Actions
Recognizes SHC proteins.
Physical form
Format: Purified
Immunoaffinity Purified immunoglobulin in 0.2 Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Protein A purified
Preparation Note
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analysis Note
Control
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
routinely evaluated by immunoblot on RIPA lysates from human A431 carcinoma cells or mouse 3T3 RIPA cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
新产品
This item has
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Z Tu et al.
Blood, 98(7), 2028-2038 (2001-09-25)
SH2-containing inositol 5'-phosphatase (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described.
Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells.
Bauckman, KA; Haller, E; Flores, I; Nanjundan, M
Cell Death & Disease null
Activation of Rac and tyrosine phosphorylation of cytokine receptors induced by cross-linking of integrin alpha4beta1 and cell adhesion in hematopoietic cells.
Eiichiro Kanda, Zhen-Hua Jin, Daisuke Mizuchi, Ayako Arai, Osamu Miura
Biochemical and biophysical research communications null
Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor.
Cicenas, J; Kung, W; Eppenberger, U; Eppenberger-Castori, S
Cancers null
Vivek Subbiah et al.
Cancer discovery, 8(7), 836-849 (2018-04-17)
The receptor tyrosine kinase rearranged during transfection (RET) is an oncogenic driver activated in multiple cancers, including non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC), and papillary thyroid cancer. No approved therapies have been designed to target RET; treatment
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