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Merck
CN

06-559

Sigma-Aldrich

Anti-Pyk2 Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PTK2B(2185)

General description

125 kDa

Immunogen

GST-fusion protein containing amino acids 726-863 of human Pyk2

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling
This Anti-Pyk2 Antibody is validated for use in IC, IP, WB for the detection of Pyk2.

Biochem/physiol Actions

Recognizes Pyk2, and its degradation products; does not cross-react with FAK.

Physical form

Format: Purified
Protein A Purified immunoglobulin in 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse brain cytosolic RIPA lysates
routinely evaluated by immunoblot on mouse brain cytosolic RIPA lysates

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rongfang Wei et al.
Cancer communications (London, England), 42(11), 1185-1206 (2022-08-31)
Multiple myeloma (MM) is the second most common hematological malignancy. An overwhelming majority of patients with MM progress to serious osteolytic bone disease. Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) participates in several steps during cancer development and osteoclast differentiation. This
Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Younes, MN; Yigitbasi, OG; Yazici, YD; Jasser, SA; Bucana, CD; El-Naggar, AK; Mills, GB; Myers, JN
Archives of Otolaryngology--Head & Neck Surgery null
Shinichi Nakano et al.
Scientific reports, 9(1), 4236-4236 (2019-03-14)
Excessive osteoclastic bone erosion disrupts normal bone remodeling and leads to bone loss in many skeletal diseases, including inflammatory arthritis, such as rheumatoid arthritis (RA) and psoriatic arthritis, periodontitis and peri-prosthetic loosening. Functional control of osteoclasts is critical for the
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.
Ssang-Taek Lim,Nichol L G Miller,Ju-Ock Nam,Xiao Lei Chen,Yangmi Lim,David D Schlaepfer
The Journal of Biological Chemistry null
Hydroxamic acid derivatives of mycophenolic acid inhibit histone deacetylase at the cellular level.
Daniela I Batovska,Dong Hoon Kim,Shinya Mitsuhashi,Yoon Sun Cho,Ho Jeong Kwon,Makoto Ubukata
Bioscience, Biotechnology, and Biochemistry null

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