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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
shipped in
dry ice
target post-translational modification
unmodified
General description
Symmetrical dimethylated arginine (sDMA) is a product of the post-translational modification, arginine methylation. sDMA is a structural isomer of asymmetric dimethylarginine.
~16 kDa
Immunogen
peptide corresponding to amino acids 99-119 of Small nuclear ribonucleoprotein SmD3.
Application
Anti-dimethyl-Arginine Antibody, symmetric (SYM11) has been used in:
- co-immunoprecipitation (co-IP)
- western blot analysis
- immunoprecipitation
Biochem/physiol Actions
SmD3 at ~16kDa, and other proteins that contain arginines that are symmetrically dimethylated
Symmetrical dimethylarginine (sDMA) is a competitor of arginine transport and is eliminated through renal excretion. sDMA serves as a marker to indicate the estimated glomerular filtration rate (GFR) and the coronary artery disease (CAD) severity. Elevated sDMA is associated with the risk of cardiovascular disease and mortality. It might also help in the early detection of chronic kidney disease. sDMA acts as an endogenous marker of renal function. It is associated with tumorigenesis.
Physical form
Format: Purified
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
routinely evaluated by immunoblot in RIPA lysates from Jurkat cells
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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