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Merck
CN

07-728

Sigma-Aldrich

Anti-HRI Antibody

serum, Upstate®

Synonym(s):

Anti-HCR, Anti-HRI, Anti-LEMSPAD, Anti-hHRI

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_014413.2

UniProt accession no.

Q9BQI3

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... EIF2AK1(27102)
mouse ... Eif2Ak1(15467)

General description

72kDa

Immunogen

6His-tagged fusion protein corres-ponding to residues 1-138 of mouse heme-regulated inhibitor (HRI)

Application

Detect HRI using this Anti-HRI Antibody validated for use in IP & WB.

Biochem/physiol Actions

HRI

Analysis Note

Routinely evaluated by immunoblot on lysates from mouse reticulocytes.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J J Chen et al.
Trends in biochemical sciences, 20(3), 105-108 (1995-03-01)
Protein synthesis is regulated by the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in a variety of cells. At present, there are two distinct mammalian eIF-2 alpha kinases that have been cloned, the double-stranded-RNA-dependent eIF-2 alpha
Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation.
Anderson, Paul and Kedersha, Nancy
Cell Stress & Chaperones, 7, 213-221 (2002)
Maryam Rafie-Kolpin et al.
Biochemistry, 42(21), 6536-6544 (2003-05-28)
In heme deficiency, protein synthesis is inhibited by the activation of the heme-regulated eIF2alpha kinase (HRI) through its multiple autophosphorylation. Autophosphorylation sites in HRI were identified in order to investigate their functions. We found that there were eight major tryptic
The eIF-2alpha kinases and the control of protein synthesis.
de Haro, C, et al.
Faseb Journal, 10, 1378-1387 (1996)
Nicolò Musner et al.
ASN neuro, 8(2) (2016-04-21)
In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 deleted (P0S63del) accumulates
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