07-822
Anti-phospho-eIF2Bε (Ser539) Antibody
Upstate®, from rabbit
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
rat, human
Application:
WB
Citations:
20
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pSer539)
Gene Information
human ... EIF2B5(8893)
General description
82 kDa
Immunogen
KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser539 of human eIF2Bε
Application
Anti-phospho-eIF2Bε (Ser539) Antibody is an antibody against phospho-eIF2Bε (Ser539) for use in WB.
Biochem/physiol Actions
Recognizes eIFB2ε phosphorylated on Ser539.
Analysis Note
Routinely evaluated by immunoblot.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 2
Certificates of Analysis (COA)
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M Kleijn et al.
FEBS letters, 476(3), 262-265 (2000-07-29)
Epidermal and nerve growth factors (EGF and NGF) activate protein synthesis and initiation factor eIF2B in rat phaeochromocytoma (PC12) cells. The activation of protein synthesis by EGF or NGF depends upon extracellular regulated kinase kinase (MEK)/extracellular regulated kinase signalling. Here
Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control
Campbell, S.G. et al.
The Journal of cell biology, 170(6), 925-934 (2005)
L S Jefferson et al.
The international journal of biochemistry & cell biology, 31(1), 191-200 (1999-04-27)
Eukaryotic initiation factor eIF2B is a guanine nucleotide exchange protein involved in regulation of translation initiation. Phosphorylation of the epsilon-subunit is thought to be important in insulin-mediated changes in eIF2B activity. However, elucidation of insulin's action has proven elusive, primarily
N Price et al.
Biochimie, 76(8), 748-760 (1994-01-01)
Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from
G I Welsh et al.
The Journal of biological chemistry, 271(19), 11410-11413 (1996-05-10)
Mitogenic stimulation of T-lymphocytes causes a rapid activation or protein synthesis, which reflects in part increased expression of many translation components. Their levels, however, rise more slowly than the rate of protein synthesis, indicating an enhancement of the efficiency of
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