114810
ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem
The ADAMTS-5 Inhibitor, also referenced under CAS 929634-33-3, controls the biological activity of ADAMTS-5. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem, 5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C16H11ClF3N3OS3
CAS Number:
Molecular Weight:
449.92
UNSPSC Code:
12352200
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
Biochem/physiol Actions
Cell permeable: no
Primary Target
ADAMTS-5
ADAMTS-5
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett.17, 1185.
Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1189.
Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1189.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
监管及禁止进口产品
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