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116814

Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt

A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM).

Synonym(s):

Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt, Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V

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About This Item

Empirical Formula (Hill Notation):
C10H11N5O5PS · 4C6H16N
CAS Number:
151837-09-1
Molecular Weight:
753.06
MDL number:
MFCD02045705
UNSPSC Code:
41106305
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
crystalline solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)
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Quality Level

100

assay

≥98% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 20 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21-;/m1./s1

InChI key

OXIPZMKSNMRTIV-RNSTXJOVSA-N

General description

A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP.
Cell permeable inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Note: 5 µmol = 2.23 mg
Note: 5 µmol = 2.23 mg.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKA
Product does not compete with ATP.
Reversible: yes
Target Ki: 11 µM against protein kinase A

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys.420, 336.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Butt, E., et al. 1990. FEBS Lett.263, 47.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.
Rothermel, J.D. 1988. Biochem. J. 251, 757.
Eckstein, F. 1985. Annu. Rev. Biochem.54, 367.
de Wit, R.J., et al. 1984. Eur. J. Biochem.142, 255.
O′Brian, C.A., et al. 1982. Biochemistry21, 4371.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
116814-5UMOL07790788047825