116833
Adenosine 3′,5′-cyclic Monophosphate, 8-(4-Chlorophenylthio)-2′-O-Methyl-, Sodium Salt
A potent, cell-permeable, and specific activator of the exchange protein activated by cyclic AMP (EPAC).
Synonym(s):
Adenosine 3′,5′-cyclic Monophosphate, 8-(4-Chlorophenylthio)-2′-O-Methyl-, Sodium Salt, 8-CPT-2ʹ-O-Me-cAMP, Na
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About This Item
Empirical Formula (Hill Notation):
C17H16ClN5O6PS · Na
Molecular Weight:
507.82
UNSPSC Code:
12352208
Assay:
≥98% (HPLC)
Form:
lyophilized
Solubility:
water: 10 mg/mL
Storage temp.:
−20°C
assay
≥98% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A potent, cell-permeable, and specific activator of the exchange protein activated by cyclic AMP (EPAC) (also called cAMP-guanine nucleotide-exchange factors or cAMP-GEF) in vitro and in vivo. Does not have any effect on protein kinase A (PKA). A useful tool to discriminate between EPAC and PKA. 5 µmol = 2.54 mg. λmax = 282 nm.
Note: 5 µmol = 2.54 mg.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kang, G., et al. 2003. J. Biol. Chem.278, 8279.
Enserink, J.M., et al. 2002. Nat. Cell Biol., 4, 901.
Enserink, J.M., et al. 2002. Nat. Cell Biol., 4, 901.
Legal Information
Sold under license of European Patent Application 02/077,219.0.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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