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119135

Adenosine A1 Receptor Agonist I, CPA

Synonym(s):

Adenosine A1 Receptor Agonist I, CPA

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About This Item

Empirical Formula (Hill Notation):
C15H21N5O4
CAS Number:
41552-82-3
Molecular Weight:
335.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00036845
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

0.8 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

1 M HCl: 100 mM, DMSO: 100 mM, ethanol: 25 mM

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]2(c3ncnc(c3nc2)NC4CCCC4)C1O[C@@H]([C@H]([C@H]1O)O)CO

InChI

1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15?/m1/s1

InChI key

SQMWSBKSHWARHU-FJFSNTMWSA-N

General description

A potent and selective agonist of adenosine A1 receptor (A1R) (Ki = 2.3 nM, 790 nM, 18.6 µM, 43nM for human A1, A2A, A2B, and A3, respectively).

Biochem/physiol Actions

Primary Target
A1
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
slight warming is required for complete solubilization in ethanol

Other Notes

Migita, H., et al. 2008. J Neurosci Res.86, 2820.
Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol.81, 1.
Monopoli, A., et al. 1994. Arzneimittelforschung.44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Global Trade Item Number

SKUGTIN
119135-25MG04055977223316