129741
α-Amanitin, Amanita sp.
Assay
≥90% (by absorbance)
form
lyophilized solid
color
white
solubility
H2O: 10 mg/mL
methanol: soluble
General description
α-Amanitin, Amanita sp. is a toxic bicyclic octapeptide isolated from mushrooms. A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes.
Toxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
Biochem/physiol Actions
RNA polymerase 2
Preparation Note
Reconstitute to a concentration ≥1 mM
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral - STOT RE 2
Target Organs
Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Regulatory Information
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C Scheurlen et al.
Zeitschrift fur Gastroenterologie, 32(7), 399-404 (1994-07-01)
Alpha-amanitin, the main toxin of the death cap fungus (Amanita phalloides) is one of the most dangerous natural poison. This toxin damages eukaryotic cells by inhibiting their transcription. Lesions are seen in cells with rapid protein synthesis, particular in liver
A Tamin et al.
Virology, 182(1), 393-396 (1991-05-01)
The locus responsible for encoding resistance to alpha-amanitin was previously mapped to the vaccinia virus (VV) HindIII N fragment by using cloned wild-type VV DNA fragments to rescue the ability of an alpha-amanitin-resistant/temperature-sensitive VV mutant (alpha rts7) to replicate under
P M Kastrop et al.
Molecular reproduction and development, 28(3), 249-254 (1991-03-01)
Bovine cumulus oocyte complexes were cultured for various periods and either denuded and orcein stained or radiolabeled with 35S-methionine or 32P-orthophosphate. Specific inhibitors were added to the culture medium to investigate mRNA and protein synthesis requirements for both nuclear and
K Baumann et al.
Protein science : a publication of the Protein Society, 3(5), 750-756 (1994-05-01)
Four amatoxin-binding proteins with KD values in the nanomolar range, 3 monoclonal antibodies and RNA polymerase II, were studied with respect to their affinities to 24 alpha-amanitin derivatives with modified side chains. From KD values we estimated the amounts of
T Wieland
International journal of peptide and protein research, 22(3), 257-276 (1983-09-01)
The results of 50 years of effort in the chemistry of Amanita toxins are reviewed. The phallotoxins, fast acting components, but not responsible for fatal intoxications after ingestion, are bicyclic heptapeptides. They combine with F-actin, stabilizing this protein against several
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