171588
Aβ42Fibrillogenesis Inhibitor III - Calbiochem
The Aβ42 Fibrillogenesis Inhibitor III controls the biological activity of Aβ42Fibrillogenesis. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem, Amyloid β42 Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH2
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C35H46N6O8
Molecular Weight:
678.78
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
Quality Level
General description
A modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood-brain barrier and acts as a β-sheet breaker. Reported to increase neuronal survival and reduce brain inflammation in a transgenic mouse model of Alzheimer’s disease, probably due to a reduction in Aβ deposits. Displays greater stability against proteolytic degradation (t1/2 >24 hours in human plasma and cerebrospinal fluid; ~ 37 minutes in blood).
A modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood/brain barrier and acts as a β-sheet breaker. Increases neuronal survival with a concomitant reduction in brain inflammation by inducing a dramatic reduction in Aβ deposition in a transgenic mouse model of Alzheimer′s disease. Displays greater stability against proteolytic degradation (t½ >24 h in human plasma and cerebrospinal fluid; ~37 min in blood).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Reduction in Aβ deposits
Reduction in Aβ deposits
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
Other Notes
Ac-Leu-Pro-Phe-Phe-Asp-NH₂
Permanne, B., et al. 2002. FASEB J.16, 860.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Related Content
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service