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Merck
CN

176880

Anisomycin, Streptomyces griseolus

Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells.

Synonym(s):

Anisomycin, Streptomyces griseolus, 2-( p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate

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About This Item

Empirical Formula (Hill Notation):
C14H19NO4
CAS Number:
22862-76-6
Molecular Weight:
265.30
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD00077650

Key Documents

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Product Name

Anisomycin, Streptomyces griseolus, Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells.

InChI

1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1

InChI key

YKJYKKNCCRKFSL-BFHYXJOUSA-N

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 100 mg/mL
methanol: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Toxic (F)

General description

Activates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.

Preparation Note

Following reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

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