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182730

Millipore

ASB-C8Ø

A zwitterionic detergent with an aromatic core that is shown to stabilize and solubilize integral membrane proteins by breaking aggregates.

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Synonym(s):
ASB-C8Ø, C8Ø, 4- n-Octylbenzoylamido-propyl-dimethylammonio Sulfobetaine, C8Ø, 4-n-Octylbenzoylamido-propyl-dimethylammonio Sulfobetaine
Empirical Formula (Hill Notation):
C23H40N2O4S
CAS Number:
216667-49-1
Molecular Weight:
440.64
MDL number:
MFCD04973641

Quality Level

300

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C23H40N2O4S/c1-4-5-6-7-8-9-12-21-13-15-22(16-14-21)23(26)24-17-10-18-25(2,3)19-11-20-30(27,28)29/h13-16H,4-12,17-20H2,1-3H3,(H-,24,26,27,28,29)

InChI key

AQVJFUZGGMXMED-UHFFFAOYSA-N

General description

A zwitterionic detergent (zwittergent®) containing an aromatic core that has been demonstrated to stabilize and solubilize integral membrane proteins by breaking aggregates. Useful for protein analysis and characterization by two-dimensional gel electrophoresis and mass spectrometry techniques. Reported to be superior to CHAPS (Cat. No. 220201) in solubilizing an ion-channel protein and a G-protein coupled receptor (GPCR). In combination with thiourea and urea, also reported to improve the recovery of hydrophobic proteins from Arabidopsis thaliana.
A zwitterionic detergent with an aromatic core that is shown to stabilize and solubilize integral membrane proteins by breaking aggregates. Useful for protein analysis and characterization by two-dimensional (2-D) gel electrophoresis and mass spectrometry techniques. Reported to be superior to CHAPS (Cat. No. 220201) in solubilizing both an anion-channel and a G-protein coupled receptor (GPCR).

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Henningsen, R., et al. 2002. Proteomics2, 1479.
Molloy, M.P. 2000. Anal. Biochem.280, 1.
Santoni, V., et al. 2000. Electrophoresis21, 3329.
Rabilloud, T., et al. 1999. Electrophoresis20, 3603.
Santoni, V., et al. 1999. Electrophoresis20, 705.
Herbert, B. 1999. Electrophoresis20, 660.
Chevallet, M., et al. 1998. Electrophoresis19, 1901.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Zwittergent is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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