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Merck
CN

197332

Sigma-Aldrich

Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem

Synonym(s):

Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem, 5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione

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About This Item

Empirical Formula (Hill Notation):
C15H9ClN4O6
CAS Number:
141266-44-6
Molecular Weight:
376.71
MDL number:
MFCD00624842
UNSPSC Code:
12352200

Key Documents

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Assay

≥95% (elemental analysis)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 2 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.

A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Bcl-2
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Milanesi, E., et al. 2006. J. Biol. Chem.281, 10066.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class Code

10-13 - German Storage Class 10 to 13

Regulatory Information

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