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200485

Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem

Synonym(s):

Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem, (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester

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About This Item

Empirical Formula (Hill Notation):
C17H26N2O4
CAS Number:
65322-89-6
Molecular Weight:
322.40
UNSPSC Code:
12352200
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assay

≥97% (TLC)

Quality Level

100

form

semisolid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellowish

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.

A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays stronger inhibition of neutral aminopeptidase than Bestatin (IC50 = 31.6 nM). Exhibits weaker activity against basic aminopeptidase (IC50 = 400.1 nM). Also reported to augment Fas- (IC50 = 235.4 nM) or TNF-α-induced apoptosis in solid tumor cell lines.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Neutral amino pepsidase
Product does not compete with ATP.
Reversible: no
Target IC50: 31.6 nM against neutral amino pepsidase

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Unstable in aqueous solution; dilute just prior to use.

Other Notes

Sekine, K., et al. 2001. Int. J. Cancer94, 485.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

10-13 - German Storage Class 10 to 13

Regulatory Information

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Certificates of Analysis (COA)

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