203671
Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem
Acts as a ligand of the adenine nucleotide translocator.
Synonym(s):
Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem
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About This Item
Empirical Formula (Hill Notation):
C28H35O7 · 3NH4
CAS Number:
Molecular Weight:
537.69
UNSPSC Code:
12352200
assay
≥92% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige-pink
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Mitochondrial mega channel
Mitochondrial mega channel
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Other Notes
Hirsch, T., et al. 1998. J. Immunol. 161, 35.
Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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Ambre M Bertholet et al.
Nature, 606(7912), 180-187 (2022-05-26)
Mitochondria generate heat due to H+ leak (IH) across their inner membrane1. IH results from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat2-6 and ADP/ATP carrier (AAC) in other tissues1,7-9, but the underlying mechanism
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