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Merck
CN

218761

Sigma-Aldrich

Caspase-9 Inhibitor I - Calbiochem

Caspase-9 Inhibitor I, CAS 210345-04-3, is a potent, cell-permeable, and irreversible inhibitor of caspase-9.

Synonym(s):

Caspase-9 Inhibitor I - Calbiochem, Z-LE(OMe)HD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C32H43FN6O10
Molecular Weight:
690.72
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to light brown

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

This product has been discontinued.



A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/72 µl) solution of Z-LEHD-FMK (Cat. No. 218841) in DMSO is also available.

A potent, cell-permeable, and irreversible inhibitor of caspase-9.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-4, caspase-5, caspase-9
Product does not compete with ATP.
Reversible: no

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Fadeel, B., et al. 1999. Leukemia 13, 719.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Z-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

Regulatory Information

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Certificates of Analysis (COA)

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Frank A Schildberg et al.
Cell and tissue research, 320(1), 91-98 (2005-02-17)
The possible protection provided by enhancement of the cAMP signal in the process of lipopolysaccharide (LPS)-induced endothelial cell death has been addressed, with special emphasis on the endoplasmic initiation of caspase-12-mediated apoptosis. Human umbilical vein endothelial cells were challenged with
W D Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 165(10), 5612-5620 (2000-11-09)
Past studies have shown that TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis in a high proportion of cultured melanoma by caspase-dependent mechanisms. In the present studies we have examined whether TRAIL-induced apoptosis of melanoma was mediated by direct activation of effector

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