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218850

Casein Kinase I Inhibitor V, LH846

Name: Casein Kinase I Inhibitor V, LH846
Brand: MM

The Casein Kinase I Inhibitor V, LH846 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Casein Kinase I Inhibitor V, LH846, N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide, N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₃ClN₂OS

CAS Number:

639052-78-1

Molecular Weight:

316.81

UNSPSC Code:

12352200

MDL number:

MFCD03786038

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

ClC1=CC2=C(SC(NC(CC3=CC=CC=C3)=O)=N2)C=C1C

InChI

1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)

InChI key

DYHAMRNAHTWYKY-UHFFFAOYSA-N

General description

A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC₅₀ = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC₅₀ =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lee, J.W., et al. 2011. Angew. Chem. Int. Ed.50, 10608.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
218850-10MG	04055977201956

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