219489
Ceramide Kinase Inhibitor, K1
Synonym(s):
Ceramide Kinase Inhibitor, K1, F-12509A Cyclic Product K1
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About This Item
assay
≥95% (mixture of enantiomers, NMR)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
ethanol: 20 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
This product has been discontinued.
A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 = ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.
Packaging
Preparation Note
Other Notes
Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem.71, 2581
Kim, J.W., et al. 2005. Biochim. Biophys. Acta1738, 82.
Legal Information
Disclaimer
Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
Certificates of Analysis (COA)
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