219493
Ceramide Kinase Inhibitor II, NVP-231
The Ceramide Kinase Inhibitor II, NVP-231 controls the biological activity of Ceramide Kinase. This small molecule/inhibitor is primarily used for Membrane applications.
Synonym(s):
Ceramide Kinase Inhibitor II, NVP-231, Adamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C25H26N3O2S
Molecular Weight:
432.56
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
tan
solubility
DMSO: 25 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC50 = 12 nM; Ki = 7.4 nM) with excellent selectivity over hDAGKα (IC50 = 5 µM) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC50 ≥10 µM) in cell-free enzymatic assays. When applied to live cells in cultures, NVP-231 effectively prevents the binding of Cer to CerK, making cellular Cer more available to other Cer metabolizing enzymes and resulting in an increased GlcCer (glucosylceramide) and SM (sphingomyelin) production in addition to the expected decrease of Cer phosphorylation.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Graf, C., et al. 2008. Mol. Pharmacol.74, 925.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service