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Merck
CN

219556

Ceranib-2

A cell-permeable, potent inhibitor of ceramidase (IC50 = 28 mM) with anti-proliferative and proapoptotic properties.

Synonym(s):

Ceranib-2, Ceranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C25H19NO3
Molecular Weight:
381.42
UNSPSC Code:
12352200
MDL number:
MFCD25977826
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

O=C(N1)C(C(/C=C/C2=CC=C(OC)C=C2)=O)=C(C3=CC=CC=C3)C4=C1C=CC=C4

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mg/mL, clear, pale yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A cell-permeable, potent inhibitor of ceramidase (IC50 = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50 = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Draper, J., et al. 2011, Mol. Cancer Ther.10, 2052.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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