219676
CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM).
Synonym(s):
CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem, 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
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About This Item
Empirical Formula (Hill Notation):
C19H17Cl2N3O2S
CAS Number:
Molecular Weight:
422.33
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738 ) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 & 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Robert, R., et al. 2008. Mol. Pharmacol.73, 478.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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