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236013

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem

Synonym(s):

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem, N-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472

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About This Item

Empirical Formula (Hill Notation):
C20H21Cl2N3OS
CAS Number:
1177728-24-3
Molecular Weight:
422.37
UNSPSC Code:
12352200
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assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

ethanol: 0.5 mg/mL, DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).

A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).

Biochem/physiol Actions

Cell permeable: no
Primary Target
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Michaux, C., et al. 2006. Eur. J. Med. Chem.41, 1446.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

10-13 - German Storage Class 10 to 13

Regulatory Information

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Global Trade Item Number

SKUGTIN
566012-1G04061832589114