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238804

Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem

Synonym(s):

Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem, 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II

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About This Item

Empirical Formula (Hill Notation):
C23H30N6O2
CAS Number:
444723-13-1
Molecular Weight:
422.52
UNSPSC Code:
12352200
MDL number:
MFCD09264153
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assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.

A highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cdk1/cyclin B
Product competes with ATP.
Reversible: no
Target IC50: 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Pennati, M., et al. 2005. Mol. Cancer Ther.4, 1328.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Storage Class

10-13 - German Storage Class 10 to 13

Regulatory Information

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Certificates of Analysis (COA)

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