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239819

CXCR2 antagonist, Cpd 19

Name: CXCR2 antagonist, Cpd 19
Brand: MM

The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.

Synonym(s):

CXCR2 antagonist, Cpd 19, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₁N₃O₄

CAS Number:

473728-67-5

Molecular Weight:

343.38

MDL number:

MFCD32671851

NACRES:

NA.51

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL, light brown

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC₅₀ = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC₅₀ = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37^°C).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
239819-2MG	04055977198935

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