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Merck
CN

263200

Dephostatin - CAS 151606-30-3 - Calbiochem

Synonym(s):

Dephostatin - CAS 151606-30-3 - Calbiochem, PTP Inhibitor VII

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About This Item

Empirical Formula (Hill Notation):
C7H8N2O3
CAS Number:
151606-30-3
Molecular Weight:
168.15
UNSPSC Code:
12352200

Key Documents

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InChI key

FGICTAQFCLUOBH-UHFFFAOYSA-N

InChI

1S/C7H8N2O3/c1-9(8-12)6-4-5(10)2-3-7(6)11/h2-4,8,12H,1H3

assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

brown

solubility

DMSO: 5 mg/mL, chloroform: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

This product has been discontinued.



Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line (IC50 = 7.7 µM). Reported to mobilize intracellular calcium stores. Could serve as a stable NO donor for S-nitrosylation of proteins.

Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in a membrane preparation from a human neoplastic T-cell line (IC50 = 7.7 µM). Inhibits homogenous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time-dependent manner.

Biochem/physiol Actions

Cell permeable: no
Primary Target
protein tyrosine phosphatase activity from human neoplastic cell line
Product competes with ATP.
Reversible: no
Target IC50: 7.7 µM against protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line

Packaging

Packaged under inert gas

Preparation Note

Streptomyces sp.
Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett.6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett.9, 1003.
Imoto, M., et al. 1993. J. Antibiot.46, 1342.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

10-13 - German Storage Class 10 to 13

Regulatory Information

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