264156-M
Caspase-3 Inhibitor II
InSolution
Synonym(s):
InSolution Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK
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About This Item
Empirical Formula (Hill Notation):
C30H41FN4O12
Molecular Weight:
668.66
UNSPSC Code:
12352200
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
clear very faintly yellow
storage temp.
−20°C
General description
A potent, cell-permeable, and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
Biochem/physiol Actions
Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Physical form
A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264155) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Analysis Note
single spot by TLC
Other Notes
Nicholson, D.W. 1996. Nat. Biotechnol.14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.0
Nicholson, D.W., et al. 1995. Nature376, 37.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.0
Nicholson, D.W., et al. 1995. Nature376, 37.
Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - (refers to pure substance)
flash_point_c
87 °C - (refers to pure substance)
Certificates of Analysis (COA)
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