Assay
≥95% (HPLC)
Quality Level
form
crystalline solid
color
white to off-white
solubility
methanol: 0.6 mg/mL
H2O: 8 mg/mL
General description
A heat-stable neurotoxin. Glutamate kainate receptor agonist that shows higher affinity for the kainate receptor than any other known kainic acid analog. Causes excessive excitation of neurons resulting in the depletion of energy stores, cellular edema, and death. Inhibits adenylate cyclase activity in neuronal membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
Glutamate kainate excitatory amino acid agonist with the highest affinity for the kainate receptor of all known kainic acid analogs. It has been used to purify the kainate receptor by affinity chromatography. Its binding to the receptor causes continuous stimulation of nerve cells leading to depletion of energy, cellular edema, and death. Its neurological effect resembles anterograde memory loss associated with Alzheimer′s disease. Inhibits adenylate cyclase activity in brain membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
Biochem/physiol Actions
Glutamate kainate receptor
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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