Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C18H12N6O
CAS Number:
Molecular Weight:
328.33
UNSPSC Code:
12352200
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
green
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C18H12N6O/c25-18-12-10-13(19-20-17(12)21-22-18)15-14-8-4-5-9-24(14)23-16(15)11-6-2-1-3-7-11/h1-10H,(H2,20,21,22,25)
InChI key
QMBDONCHHMIWFJ-UHFFFAOYSA-N
General description
A cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Aurora B kinase
Aurora B kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 95% inhibition at 10 µM using 1 µM; [ATP]
Packaging
Packaged under inert gas
Other Notes
Anastassiadis, T., et al. 2013. J. Biol. Chem.288, In press.
Gao, Y., et al. 2013. Biochem. J.in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun.336, 357.
Gao, Y., et al. 2013. Biochem. J.in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun.336, 357.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service