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344281-M

Forskolin, NKH477

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.

Synonym(s):

Forskolin, NKH477, 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl

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About This Item

Empirical Formula (Hill Notation):
C27H43NO8 · xHCl
CAS Number:
138605-00-2
Molecular Weight:
509.63 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00236421
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
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Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 10 mg/mL

storage temp.

2-8°C

InChI

1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1

InChI key

VIRRLEDAYYYTOD-YHEOSNBFSA-N

General description

A cell-permeable and water-soluble Forskolin (Cat. No. 344270 ) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

Other Notes

Nakashima, S., et al. 2005. J. Heart Lung Transplant.24, 462.
Morinobu, S., et al. 1999. J. Neurochem.72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol.123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol.30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev.13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol.19, 625.
Shafiq, J., et al. 1992. Circ. Res.71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol.183, 2110.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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