Key Documents

View All Documentation

344301

sFRP Inhibitor II

Name: sFRP Inhibitor II
Brand: MM

The sFRP Inhibitor II, also referenced under CAS 302804-57-5, controls the biological activity of sFRP. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Synonym(s):

sFRP Inhibitor II, Wnt Pathway Activator V, 2-(2-(2-Imino-4-oxo-thiazolidin-5-yl)-acetylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester, Secreted Frizzled Related Protein-1 Inhibitor II

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₇N₃O₄S₂

CAS Number:

302804-57-5

Molecular Weight:

355.43

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

Description

General description

A cell-permeable iminooxothiazolidine compound that is shown to counteract the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and restore cellular response to Wnt-3 stimulation (by a 2.3-fold enhancement at 15 µM) in U2OS-based reporter assays. Also reported to increase total bone area and the number of osteoblasts (by ~20% and ~45%, respectively) in a murine ex vivo calvarial bone formation assay.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shi, M., et al. 2009. Bioorg. Med. Chem. Lett.19, 6337.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c