346110
Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem
A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor ligand with a binding affinity that is 4-fold higher than that of Dexamethasone.
Synonym(s):
Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem, 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
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About This Item
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
water: 1 mg/mL, DMSO: 10 mg/mL, anhydrous ethanol: 5 mg/mL
shipped in
wet ice
storage temp.
−70°C
General description
This product has been discontinued.
A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
Biochem/physiol Actions
A nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
Preparation Note
Other Notes
Legal Information
Disclaimer
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
This item has
Certificates of Analysis (COA)
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