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Merck
CN

362338

Glyco-SNAP-1 - Calbiochem

A water-soluble nitric oxide (NO) donor.

Synonym(s):

Glyco-SNAP-1 - Calbiochem, N-(β-D-Glucopyranosyl)-N²-acetyl-S-nitroso-D,L-penicillaminamide

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About This Item

Empirical Formula (Hill Notation):
C13H23N3O8S
Molecular Weight:
381.40
UNSPSC Code:
12352200

Key Documents

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assay

≥96% (NMR)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

green

solubility

aqueous buffer: 100 mg/mL, water: 100 mg/mL, methanol: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A water-soluble and stable nitric oxide (NO) donor (t½ = 28.5-30.2 hr). Glyco-SNAP-1 is more stable than SNAP (Cat. No. 487910) in aqueous solution with or without EDTA and is relatively stable at high pH (pH 8-9). The SNAP moiety acts as an NO group donor and the sugar fragment provides hydrophilicity and specificity. Compared to SNAP, glyco-SNAP-1 decomposes much more slowly in the presence of thiols such as cysteine or glutathione.
A water-soluble nitric oxide (NO) donor. More stable (t½ = 28.5-30.2 hr) than SNAP (Cat. No. 487910) in aqueous solution with or without EDTA and is relatively stable at high pH (pH 8 - 9). The SNAP moiety acts as an NO group donor and the sugar moiety provides hydrophilicity and specificity. Compared to SNAP, glyco-SNAP-1 decomposes at a much slower rate in the presence of thiols such as cysteine or glutathione.

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
A water-soluble nitric oxide (NO) donor

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Hou, Y., et al. 1999. Methods Enzymol. 301, 242.
Ramirez, J., et al. 1996. Bioorg. Med. Chem. Lett.6, 2575.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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