Skip to Content
Merck
CN

370690

Z-Guggulsterone

A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels.

Synonym(s):

Z-Guggulsterone, GS, trans-, trans-4,17(20)-Pregnadiene-3,16-dione

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C21H28O2
Molecular Weight:
312.45
UNSPSC Code:
12352200

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Z-Guggulsterone, A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels.

color

white

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Analysis Note

Single spot by TLC

Biochem/physiol Actions

Cell permeable: no
Primary Target
Farnesoid X receptor (FXR)
Product does not compete with ATP.
Reversible: no
Target IC50: 10 µM as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation in the presence of 100 µM chenodeoxycholic acid

Disclaimer

Toxicity: Standard Handling (A)

General description

A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).

Other Notes

Cui, J., et al. 2003. J. Biol. Chem.278, 10214.
Urizar, N.L., et al. 2002. Science296, 1703; Chander, R., et al. 1996. Phytotherapy Res.10, 508.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yue Jia et al.
Neurochemical research, 46(7), 1725-1736 (2021-04-07)
Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service