371545
Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem
G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.
Synonym(s):
Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem, GTPγ-S, 4Li
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About This Item
Empirical Formula (Hill Notation):
C10H12N5O13P3S · 4Li
CAS Number:
Molecular Weight:
562.98
UNSPSC Code:
12352200
MDL number:
assay
≥85% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
impurities
≤12% GDP
color
white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
G-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P3 formation in membranes.
G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
Biochem/physiol Actions
Cell permeable: no
Primary Target
G-protein-activating GTP analog
G-protein-activating GTP analog
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
Other Notes
Iino, S., et al. 2000. FEBS Lett.479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem.267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci.49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol.422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Orellana, S., et al. 1987. J. Biol. Chem..262, 1638.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem.267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci.49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol.422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Orellana, S., et al. 1987. J. Biol. Chem..262, 1638.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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